Cathodic Stripping Voltammetric Determination of Lisinopril in Dosage Forms and Biological Fluids

Al–Farhan, Badriah Saad; Gahlan, Ahmed A.; Haredy, Ahmed M.; Fraghly, Othman A.

doi:10.21608/ejchem.2021.104642.4835

Cathodic Stripping Voltammetric Determination of Lisinopril in Dosage Forms and Biological Fluids

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Girls for Science, King Khalid University, Abha, Kingdom of Saudi Arabia

² Chemistry Department, Faculty of Science, Al –Azhar University, Assiut Branch, 71524, Assiut, Egypt

³ Pharmaceutical Analytical Department, Faculty of Pharmacy, Merit University, New Sohag, Egypt

⁴ Chemistry Department, Faculty of Science, Al Baha University, Al Baha, Kingdom of Saudi Arabia

10.21608/ejchem.2021.104642.4835

Abstract

Lisinopril (LSP) in pharmaceutical dosage forms and biological fluids was studied using the square wave cathodic stripping voltammetric method (SWCSV) at a carbon paste electrode (CPE). To maximize the method's circumstances, many parameters were defined. The linear concentration range of 3.53 – 44.17 ng/mL was effectively determined at ideal conditions of 0.08 M Britton-Robinson buffers (pH = 9.00) at accumulation times 15, 30 sec., and 2.64 – 44.17 ng/mL at 60 sec. With good results, the standard addition method was employed to determine LSP in pure solutions, tablets, and biological fluids. The proposed method is compared to the previously published standard method.

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