Cathodic Stripping Voltammetric Determination of Lisinopril in Dosage Forms and Biological Fluids

Document Type : Original Article


1 Chemistry Department, Faculty of Girls for Science, King Khalid University, Abha, Kingdom of Saudi Arabia

2 Chemistry Department, Faculty of Science, Al –Azhar University, Assiut Branch, 71524, Assiut, Egypt

3 Pharmaceutical Analytical Department, Faculty of Pharmacy, Merit University, New Sohag, Egypt

4 Chemistry Department, Faculty of Science, Al Baha University, Al Baha, Kingdom of Saudi Arabia


Lisinopril (LSP) in pharmaceutical dosage forms and biological fluids was studied using the square wave cathodic stripping voltammetric method (SWCSV) at a carbon paste electrode (CPE). To maximize the method's circumstances, many parameters were defined. The linear concentration range of 3.53 – 44.17 ng/mL was effectively determined at ideal conditions of 0.08 M Britton-Robinson buffers (pH = 9.00) at accumulation times 15, 30 sec., and 2.64 – 44.17 ng/mL at 60 sec. With good results, the standard addition method was employed to determine LSP in pure solutions, tablets, and biological fluids. The proposed method is compared to the previously published standard method.


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