Green-synthesis of Platinum Nanoparticles using Olive Leaves Extracts and its Effect on Aspartate Aminotransferase Activity

Mohammed, Srwa Hashim; Rheima, Ahmed; Al-jaafari, Firas; Al-Marjani, Mohammed F.; Abbas, Zainab

doi:10.21608/ejchem.2021.91747.4355

Green-synthesis of Platinum Nanoparticles using Olive Leaves Extracts and its Effect on Aspartate Aminotransferase Activity

Document Type : Original Article

Authors

¹ Department of Chemistry, College of education, University of garmian, Kalar, Iraq

² Chemistry department, science college, Wasit university, Al Kut Iraq

³ Physics Department, College of Science, Wasit University, Kut, Iraq

⁴ Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq

⁵ Department of Dentistry, Kut University College, Kut, Wasit , Iraq

10.21608/ejchem.2021.91747.4355

Abstract

This study aims to synthesize Platinum nanoparticles (Pt NPs) using Olive leaves extract's environmentally friendly approach. UV-Visible spectroscopy has been used to follow the turning of Pt +4 ions to Pt0 NPs. X-ray diffraction (XRD) has been used to investigate the as-synthesized Pt NPs and its cubic face-centered structure crystallinity. The average size of nanoparticles was 9.2 nm, calculated by transmission electron microscopy (TEM). The activity of as-synthesized Pt NPs has been examined by inhibition of Serum Aspartate Aminotransferase (AST) level in patients with chronic liver disease and control group, The AST (mean= 12.8051.642) demonstrate a very significant rise (p < 0.01) in the results. In chronic liver patients with Pt NPs, serum AST activity was significantly lower (p < 0.01) than in patients without Pt NPs (mean=13.4582.360). The present study concluded that Platinum nanoparticles play a great role in inhibition of AST.

Keywords

Main Subjects