Cardioprotective effect of melatonin on ischemic heart disease clinical course in elderly patients with insomnia

Osadchuk, Mikhail A.; Vasil`eva, Inna N.; Korzhenkov, Nikolay P.; Mironova, Ekaterina D.; Trushin, Maxim V.

doi:10.21608/ejchem.2021.93831.4420

Cardioprotective effect of melatonin on ischemic heart disease clinical course in elderly patients with insomnia

Document Type : Original Article

Authors

¹ Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

² Kazan Federal University, Kazan, Russia

10.21608/ejchem.2021.93831.4420

Abstract

We aimed at studying the exogenous melatonin corrective effect on Ischemic heart disease (IHD) clinical features in elderly patients with sleep disorders. A total of 60 patients aged from 60 to 74 with IHD, angina pectoris functional class (FC) II and complaints of sleep disorder were examined. Patients of the 1st group (n = 30), received basic therapy: acetylsalicylic acid, atorvastatin and metoprolol succinate. A chemical melatonin analogue once a day was added to the basic treatment regimen of patients of the 2nd group (n = 30). Timely correction of melatonin pathogenetic deficiency in elderly IHD patients with insomnia by including its pharmacological analogues in the treatment regimen manifests significant improvement in the patients` clinical condition. This is evidenced by the following: a decrease in anginal attacks frequency, dynamics in Holter electrocardiographic study (ECG) monitoring indicators and somnological characteristics.

Keywords

Main Subjects