Cardioprotective effect of melatonin on ischemic heart disease clinical course in elderly patients with insomnia

Document Type : Original Article


1 Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

2 Kazan Federal University, Kazan, Russia


We aimed at studying the exogenous melatonin corrective effect on Ischemic heart disease (IHD) clinical features in elderly patients with sleep disorders. A total of 60 patients aged from 60 to 74 with IHD, angina pectoris functional class (FC) II and complaints of sleep disorder were examined. Patients of the 1st group (n = 30), received basic therapy: acetylsalicylic acid, atorvastatin and metoprolol succinate. A chemical melatonin analogue once a day was added to the basic treatment regimen of patients of the 2nd group (n = 30). Timely correction of melatonin pathogenetic deficiency in elderly IHD patients with insomnia by including its pharmacological analogues in the treatment regimen manifests significant improvement in the patients` clinical condition. This is evidenced by the following: a decrease in anginal attacks frequency, dynamics in Holter electrocardiographic study (ECG) monitoring indicators and somnological characteristics.


Main Subjects

  • Receive Date: 01 September 2021
  • Revise Date: 13 October 2021
  • Accept Date: 19 October 2021
  • First Publish Date: 19 October 2021