Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study

Document Type : Original Article


1 biological anthropology department, National Research Centre, Giza, Egypt.

2 Clinical Genetics Department, National Research Centre, Cairo, Egypt.

3 Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt.

4 Internal Medicine Faculty of Medicine, Al-Azhar University- Girls.

5 Medical Department, Medical Research Division, National Research Centre, Giza, Egypt.

6 Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

7 Department of medical biochemistry National Research Centre, Giza, Egypt.


Background: Brain-derived neurotrophic factor (BDNF) is a crucial moderator of neuronal plasticity in adults, a potential association between BDNF and depression has been reported. Besides BDNF plays a role in glucose and energy metabolism. Methods: This work included 180 women (25-55 years old). Ninety diabetic patients with the clinical diagnosis of depression and 90 were normal controls. Plasma BDNF was evaluated using ELISA. The Zung Self‑Rating Depression Scale (SDS) consisting of 20 objects with a Likert‑type scale after each was used. HbA1c were measured in each patient using a clinical auto-analyzer. Results: BDNF levels in serum decreased significantly in diabetic depressed women compared to controls. Moreover, BDNF levels were inversely proportional to age, BMI, HbAc1 and LDL.Conclusion: The study suggests that age, BMI, HbAc1 have a definite impact on the circulating levels of BDNF in peripheral blood. The outcomes delineate that BDNF could participate in glucose impairment and lipid metabolism in diabetic patients.


Main Subjects

Volume 65, Issue 2 - Serial Number 2
February 2022
Pages 175-179
  • Receive Date: 03 July 2021
  • Revise Date: 20 August 2021
  • Accept Date: 29 August 2021
  • First Publish Date: 29 August 2021