Green synthesis: Antimicrobial activity of novel benzothiazole-bearing coumarin derivatives and their fluorescence properties

Metwally, Nadia Hanafy; El-gemeie, Galal; Fahmy, Fatma Gomaa

doi:10.21608/ejchem.2021.91887.4365

Green synthesis: Antimicrobial activity of novel benzothiazole-bearing coumarin derivatives and their fluorescence properties

Document Type : Original Article

Authors

¹ Chemistry, Faculty of Science, Cairo University, Giza, Egypt

² Chemistry department, Faculty of Science, Helwan University.

³ Chemistry department, Faculty of Science, Cairo University

10.21608/ejchem.2021.91887.4365

Abstract

A new benzothiazole derivatives 4a-f were prepared by the reaction of2-cyanomethylbenzothiazole 1 with 2-hydroxy-5-(aryldiazenyl)benzaldehyde derivatives 2a-f under conventional method in ethanol containing few drops of triethylamine. The previous reaction was reinvestigated at room temperature using grindstone techniques in the presence of sodium hydroxide. The compounds 4a-f transformed into benzothiazole-bearing coumarin derivatives 5a-f by refluxing in dioxane with few drops of conc. hydrochloric acid. The structure of the newly synthesized compounds 4a-f and 5a-f was established by spectral data. The compounds 5a-f showed fluorescence properties as well as antimicrobial activity.

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