Spectrophotometric Determination of Salbutamol and Terbutaline using 9-Chloroacridine Reagent

Document Type : Original Article


1 Chemistry Department, College of Science, Duhok University

2 Chemistry Department, College of Education for pure science, Mosul University


A simple and sensitive spectrophotometric method has been described for the assay of Salbutamol sulphate (SBS) and Terbutaline sulphate (TERS) in their pure and dosage forms. The method was based on the reaction of the nucleophilic compensation by interacting of drugs with the reagent 9-chloroacridine (9-CA) in basic medium. The products have absorption bands with maximum absorbance at 600 nm and 588 nm for SBS and TERS respectively. Beer’s law was obeyed in the range 0.5-12.0 μg.ml-1 and 0.1-6.0 μg.ml-1 with molar absorptivity values 1.913×104 and 1.0755×105 l.mol-1.cm-1, recoveries are 101.3% and 99.6% for above drugs respectively. The relative standard deviation (RSD) is less than 1.7% for both drugs. The probable reactions have been suggested.


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