Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent

Elsabagh, Mohammed F. Elsabagh; Fayez, Hend; Motaleb, Mohammed A.; Zaghary, Wafaa A.; Sakr, Tamer M.

doi:10.21608/ejchem.2021.85086.4150

Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent

Document Type : Original Article

Authors

¹ Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

³ Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

10.21608/ejchem.2021.85086.4150

Abstract

Graphene is a crystalline form of carbon that is regarded as a novel and innovative product. carboxylated nanographene oxide sheets (NGO-COOH) was synthesized using a modified Hummer's method and assess their medical significance. NGO-COOH were successfully synthesized with an average size of 40 nm. FT-IR, UV–Vis, XPS spectrophotometry, and TEM were used to thoroughly describe them. The cytotoxicity function of NGO-COOH nanosheets were tested against cell line. The radiosynthesized [99mTc]Tc-NGO-COOH had a high radiolabeling yield (97.3±0.45 %). The tumor uptake of [99mTc]Tc-NGO-COOH nanosheets in an in vivo biodistribution model in tumor-bearing mice was high. NGO-COOH nanosheets may be a promising imaging agent, based on these findings.

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