Cationic Copolymers Based On Styrene And N,N-Dimethylaminoethyl Methacrylate For Antibacterial Activity Applications

Document Type : Original Article

Authors

1 polymers and pigment deprtment, National Research Center, Egypt

2 Department of Microbiology and Immunology, National Research Centre

3 polymers and pigments department, national Research Center, Egypt

Abstract

Cationic copolymers based on both styrene and N,N-dimethylaminoethyl methacrylate monomers were synthesized. Styrene monomer is reactedwith N,N- dimethylaminoethyl methacrylate (DMAEMA) monomer through conventional free radical polymerization. This reactionwas performedusing styrene to DMAEMA ratios of 1:0.25, 1:0.5, 1:1, and 1:2 molesto form copolymers SD0.25, SD0.5, SD1, and SD2, respectively.The resultant copolymers are characterized by Fourier transforms infrared (FTIR) spectroscopy, and proton nuclear magnetic resonance (1HNMR) spectroscopy. The surface morphology is studied using field emissionscanning electron microscope (FESEM). The positive charge was introduced to the formed copolymers through alkylation with hexyl bromide forming the corresponding cationiccopolymers; CSD0.25, CSD0.5, CSD1, and CSD2, respectively.The cationic copolymers are characterized by FTIR, 1HNMR, wide angle X-ray diffraction (WAXRD), thermogravimetric analysis (TGA) and FESEM. The antibacterial activity ofthe copoylmers and their cationic forms are tested againstEscherichia coliserotype O145 (E. ColiO145) and Staphylococcus aureus (S. aureus)strains.CSD0.5 and CSD1 are found to have promising antibacterial activity against both bacterial strains.

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Volume 65, Issue 1 - Serial Number 1
January 2022
Pages 125-132
  • Receive Date: 02 June 2021
  • Revise Date: 11 July 2021
  • Accept Date: 15 July 2021
  • First Publish Date: 15 July 2021