Synthesis of 3-Dimensional Chitosan/Carboxymethyl Cellulose/ZnO Biopolymer Hybrids by Ionotropic Gelation for Application in Drug Delivery

Document Type : Original Article


1 Chemistry Department, Faculty of Science, Mansoura University, Mansoura, ET-35516-Egypt

2 Institute of Materials Science (ICMUV) Universitat de València C/ Catedràtic José Beltrán 2 46980 Paterna, València, Spain

3 Chemistry Department, Faculty of Science, Mansoura University, 35516-Mansoura, Egypt


Chitosan and CMC as biopolymers and ecofriendly compounds were self-assembled to form 3-dimensional network and hybrid with ZnO nanoparticles, CS/ZnO-CMC/CaCl2 was used as a carrier for in-vitro release of 5-FU as a drug model depending on pH sensitivity emulated to the human gastrointestinal medium. The drug loading capacity and entrapment efficiency were investigated. Swelling behavior of the prepared systems by different concentrations of the raw materials and cumulative release of 5-flourouracil were studied at pH 2.1 and 7.4. Kinetic studies were applied on the drug release data using Korsmeyer-peppas as a kinetic equation model to identify the diffusion mechanism. The prepared copolymers were characterized by Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA) and scanning electronic microscopy (SEM).


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