Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives

Document Type : Original Article


Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.


New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzoylisothiocyanate and aminopyrazoles. The antimicrobial activities were also studied and have been found that; Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species


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