Synthesis, structural, thermal and biological studies for new Schiff base derived from Isoniazid and it's complexes with metal ions

Document Type : Original Article


1 College of Remote Sensing & Geophysics , Al Karkh University of Science, Baghdad, Iraq

2 Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq


A new ligand of Schiff base (L") [methyl (E)-(6-((2-isonicotinoylhydrazineylidene) (phenyl) methyl) -1H - benzo[d]imidazol-2’-yl) carbamate] (3) was prepared from the reaction of isoniazid (1) and mebendazole (2) in presence of HBr (48%) in ethanol. The complexes were prepared from the reaction metal ions M(II)=V, Mn, Co, Ni, Cu, Cd, Zn, and Hg with (L") in ethanol and acetone. All compounds were characterized by FT-IR, 1H NMR,13C NMR, UV.Vis, Mass spectroscopy, magnetic susceptibility measurements, atomic absorption, thermal analyses, elemental microanalysis, molar conductance, and chloride content. The results obtained when evaluating the antibacterial and antifungal activities of the compounds prepared against two types of bacteria and one type of fungi showed that the complexes are more effective than free ligand, while based on a date for all techniques It has been suggested that all prepared complexes have octahedral geometry.


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