A simple, sensitive and green spectrophotometric method for the determination of metoclopramide hydrochloride (MTC) has been developed. The method is based on the reaction of MTC with p-dimethylaminobenzaldehyde (DAB) in acidic aqueous medium (pH 2) in the presence of anionic surfactant sodium dodecyl sulfate (SDS) to give a yellow colored Schiff’s base with a maximum absorbance at 452 nm. Obedience to Beer’s law is achieved in the concentration range 0.2–18.0 µg ml-1 (5.6×10-7 - 5.1×10-5 mol l-1), with relative error about 1%, relative standard deviation of less than 0.8% and molar absorptivity 3.02×10-4 l mol-1cm-1. The effect of the presence of some common pharmaceutical additives has been investigated. The developed procedure has been successfully applied to the determination of the drug in pharmaceutical formulations.
Thanoon, E. S., & Saeed, A. M. (2021). Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride. Egyptian Journal of Chemistry, 64(7), 3451-3456. doi: 10.21608/ejchem.2021.43857.2923
MLA
Enas S. Thanoon; Abdussamed M.A. Saeed. "Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride", Egyptian Journal of Chemistry, 64, 7, 2021, 3451-3456. doi: 10.21608/ejchem.2021.43857.2923
HARVARD
Thanoon, E. S., Saeed, A. M. (2021). 'Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride', Egyptian Journal of Chemistry, 64(7), pp. 3451-3456. doi: 10.21608/ejchem.2021.43857.2923
VANCOUVER
Thanoon, E. S., Saeed, A. M. Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride. Egyptian Journal of Chemistry, 2021; 64(7): 3451-3456. doi: 10.21608/ejchem.2021.43857.2923