Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode

Gahlan, Ahmed Abdelmogod; Derayea, Sayed Mohamed; Omar, Mahmoud Ahmed; Saleh, Gamal Ahmed; Haredy, Ahmed Mogahed

doi:10.21608/ejchem.2021.48845.2999

Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt

² Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

³ Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Minia

⁴ Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

10.21608/ejchem.2021.48845.2999

Abstract

A new simple, cheap, and rapid method to increase the sensitivity of pencil graphite electrode (PGE) to determine Linagliptin (LNG) was developed by modified PGE with copper microparticles (Cu-PGE). The disposable modified sensor electrode's preparation depended on the electrodeposition of Cu-microparticles on the PGE that can be applied for determined LNG by complexed it with Cu+2 ions and measure the LNG-Cu complex onto the Cu-PGE improved. The preparation of this modified electrode is easy, simple, and cheap, and has high sensitivity. The modified electrode detected the LNG in the LNG-Cu complex range from 47.25 - 283.53 ng mL-1 with detection and quantitative limits of 6.0 and 20.0 ng mL-1, respectively, with a correlation coefficient of 0.9995. The proposed method was applied with success to determined LNG in the dosage form, spiked urine, and spiked plasma samples; additionally, the obtained modified electrode was put in comparison with the reported electrodes.

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