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Egyptian Journal of Chemistry
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Kotb, E., Soliman, H., Hassan, E., Negm El-Dein, A. (2021). Convenient synthesis of new indeno[1,2-b]pyridine derivatives for antimicrobial and antioxidant evaluation. Egyptian Journal of Chemistry, 64(3), 10-11. doi: 10.21608/ejchem.2020.49035.3007
Eman Rashad Kotb; Hanan A Soliman; Eman Mostafa Hassan; Asmaa Negm El-Dein. "Convenient synthesis of new indeno[1,2-b]pyridine derivatives for antimicrobial and antioxidant evaluation". Egyptian Journal of Chemistry, 64, 3, 2021, 10-11. doi: 10.21608/ejchem.2020.49035.3007
Kotb, E., Soliman, H., Hassan, E., Negm El-Dein, A. (2021). 'Convenient synthesis of new indeno[1,2-b]pyridine derivatives for antimicrobial and antioxidant evaluation', Egyptian Journal of Chemistry, 64(3), pp. 10-11. doi: 10.21608/ejchem.2020.49035.3007
Kotb, E., Soliman, H., Hassan, E., Negm El-Dein, A. Convenient synthesis of new indeno[1,2-b]pyridine derivatives for antimicrobial and antioxidant evaluation. Egyptian Journal of Chemistry, 2021; 64(3): 10-11. doi: 10.21608/ejchem.2020.49035.3007

Convenient synthesis of new indeno[1,2-b]pyridine derivatives for antimicrobial and antioxidant evaluation

Article 40, Volume 64, Issue 3, March 2021, Page 10-11  XML
Document Type: Original Article
DOI: 10.21608/ejchem.2020.49035.3007
Authors
Eman Rashad Kotb email orcid 1; Hanan A Soliman2; Eman Mostafa Hassan3; Asmaa Negm El-Dein4
1Photochemistry Department, NRC
2Photochemistry deprtment, NRC
3Photochemistry department, NRC
4Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Researches Division, National Research Centre, Dokki, Egypt
Receive Date: 08 November 2020,  Revise Date: 27 November 2020,  Accept Date: 06 December 2020 
Abstract
A new set of 1H-indenopyrdine-based derivatives were synthesized using the compound 4-(4-hydroxy-3-methoxyphenyl)-2-oxo-2,5-dihydro-1H-indeno[1,2-b]pyridine-3-carbonitrile (1) as the key starting compound. The molecular structures of the new derivatives were identified using various spectroscopic techniques and elemental analysis. All the new analogues were screened as antimicrobial against different strains of +ve gm, -ve gm bacteria and the opportunistic pathogenic yeast C. albicans. Some of the new indenopyrdines exhibited moderate antimicrobial activity comparing to gentamicin as a standard drug. On the reverse, the free radical scavenging activity of the new compounds using DPPH assay protocol revealed that most of the compounds were potent antioxidant agents while comparing to ascorbic acid as a positive antioxidant control.
Keywords
1H- indenopyrdine; Schiff’s bases; Thiazolidinone ring; Antimicrobial activity; Antioxidant
Main Subjects
Organic chemistry
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