Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives

Mutlaq, Dakhil Zughayir; Al-Shawi, Ali A. A.; AbdulJabar, Layla Adnan

doi:10.21608/ejchem.2020.47419.2963

Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Education for Pure Sciences, University of Basrah , Basrah, Iraq

² Chemistry Department University of Basrah College of Education for Pure Sciences

³ Department of Physiology, Medicines and Biochemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq

10.21608/ejchem.2020.47419.2963

Abstract

Four new 2-thiohydantoin derivatives (4a-d) were synthesized from the reaction of maleimide derivatives (3a-d) with phenylisothiocyanate. The structures of synthetic compounds were characterized using Fourier-transform infrared spectroscopy (FT-IR), 1H- and 13C-nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. The antioxidant activity of the synthesized compounds showed inactive 4b and 4c compounds, moderately active 4a, and strongly active 4d, compared with vitamin C as positive control (IC50 values = 1.380, 1.726, 4.147, 8.085, and 9.826 µM, respectively). Antibacterial and antifungal activities of compounds showed that only compound 4b had an effect on Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger species.

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