Mutlaq, D., Al-Shawi, A., AbdulJabar, L. (2021). Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives. Egyptian Journal of Chemistry, 64(3), 1315-1321. doi: 10.21608/ejchem.2020.47419.2963
Dakhil Zughayir Mutlaq; Ali A. A. Al-Shawi; Layla Adnan AbdulJabar. "Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives". Egyptian Journal of Chemistry, 64, 3, 2021, 1315-1321. doi: 10.21608/ejchem.2020.47419.2963
Mutlaq, D., Al-Shawi, A., AbdulJabar, L. (2021). 'Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives', Egyptian Journal of Chemistry, 64(3), pp. 1315-1321. doi: 10.21608/ejchem.2020.47419.2963
Mutlaq, D., Al-Shawi, A., AbdulJabar, L. Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives. Egyptian Journal of Chemistry, 2021; 64(3): 1315-1321. doi: 10.21608/ejchem.2020.47419.2963
Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives
1Department of Chemistry, College of Education for Pure Sciences, University of Basrah , Basrah, Iraq
2Chemistry Department
University of Basrah
College of Education for Pure Sciences
3Department of Physiology, Medicines and Biochemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
Receive Date: 22 October 2020,
Revise Date: 16 November 2020,
Accept Date: 30 November 2020
Abstract
Four new 2-thiohydantoin derivatives (4a-d) were synthesized from the reaction of maleimide derivatives (3a-d) with phenylisothiocyanate. The structures of synthetic compounds were characterized using Fourier-transform infrared spectroscopy (FT-IR), 1H- and 13C-nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. The antioxidant activity of the synthesized compounds showed inactive 4b and 4c compounds, moderately active 4a, and strongly active 4d, compared with vitamin C as positive control (IC50 values = 1.380, 1.726, 4.147, 8.085, and 9.826 µM, respectively). Antibacterial and antifungal activities of compounds showed that only compound 4b had an effect on Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger species.
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