Synthesis, Antimicrobial, Antioxidant and Structural Studies of Some New Sulfa Drug Containing an Azo-azomethine Group

Jadou, Bushra Kamel; Hameed, Ali Jamil; Al-Rubaie, Ali Zayed

doi:10.21608/ejchem.2020.43195.2872

Synthesis, Antimicrobial, Antioxidant and Structural Studies of Some New Sulfa Drug Containing an Azo-azomethine Group

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Sciences, University of Basrah, Iraq

² 1- Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq. 2- College of Pharmacy, Al-Ayen University, Nasiriya, Thi-Qar, Iraq

10.21608/ejchem.2020.43195.2872

Abstract

A new series of azo-azomethine compounds derived from sulfadiazine were prepared. The compounds were prepared, starting from the coupling of the sulfadiazine diazonium salt with 2- hydroxy -3- methoxy benzaldehyde, followed by condensation with 4-bromoaniline, 2- chloroaniline, 2- methyl-3-chloroaniline, sulfadiazine, 2,4-dimethylaniline, and 2- hydroxyaniline, respectively. All compounds were characterized by CHN analyses, FT-IR, and NMR spectroscopic data. The antimicrobial activity of all synthesized compounds was studied against gram-positive and gram-negative bacteria and fungi. They were screened for their antibacterial activities towards the gram-positive Staphylococcus aureus and the gram-negative Escherichia coli, as well as their antifungal activities against Aspergillus niger, candidaalbicane, and Candida glabrata, to evaluate their antimicrobial potential. Furthermore, their antioxidant activities were investigated by using the β – Carotene bleaching method. QSAR Properties and Molecular properties of all compounds were obtained by using Hyperchem software.

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