The Use of Green Spectroscopy for Analysis of Quetiapine

Document Type : Original Article

Authors

1 Department of Pharmaceutical Chemistry, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt

2 Menoufia University

3 Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt

4 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour 25511, Egypt

5 Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

Abstract

Three green (eco-friendly), inexpensive and simple spectrophotometric methods for quetiapine fumarate (QTF) analysis have been developed and validated. Method I was based on the measurement of the oxidation product of QTF at 610 nm. Potassium permanganate was used as oxidant. Method II was also relay on oxidation of the drug with ceric ammonium sulfate and the decrease in absorption intensity at 315 nm was measured. Method III involved complexation of the analyte with 2´,7´-bis (acetoxy mercury) fluorescein and quantitative analysis depended on determination of the reduction in absorption intensity of the used reagent at 502 nm. Different reaction conditions affecting intensity of measurement were carefully studied, optimized and validated. In all proposed methods, no need for extraction procedures and there were linear relationships between the absorbance readings and concentrations of QTF in the range of 5-35, 1-6 and 30-100 μg/mL with LOD values 1.11, 0.12 and 2.68 μg/mL for methods I, II and III respectively. The suggested methods were successfully applied to QTF analysis in pure form and in drug tablets.

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History

  • Receive Date: 29 July 2020
  • Revise Date: 27 August 2020
  • Accept Date: 30 August 2020

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