Formulation of Mouth Dissolving Strips of Metoprolol Succinate Using Locust Bean Gum

Bala, Rajni; Madaan, Reecha; Gupta, Radha; Chawla, Rakesh; Sahoo, Ujjwal

doi:10.21608/ejchem.2020.38329.2789

Formulation of Mouth Dissolving Strips of Metoprolol Succinate Using Locust Bean Gum

Document Type : Original Article

Authors

¹ Chitkara college of Pharmacy Chitkara University Punjab

² Chitkara College of Pharmacy, Chitkara University, Punjab India

³ Chitkara College of Pharmacy, Chitkara University, Punjab, India

⁴ Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot

⁵ Dr. B C Roy College of PHARMACY and AHS

10.21608/ejchem.2020.38329.2789

Abstract

The current project was carried out to investigate the use of locust bean gum as a film forming agent in the development of fast dissolving oral strips that can be utilized for the drug administration in urgent situations such as convulsive seizures, hypertension and dysphasia. Oral strips of locust bean gum were formulated using solvent casting method containing metoprolol succinate as model drug. (T1- T9) placebo films were formulated initially using different concentrations of locust bean gum to assess the film forming ability of the locust bean gum. Crospovidone and PEG-200 were used as disintegrating agent and plasticizer respectively. Stability against moisture was improved by addition of beeswax. Formulated films (T1-T9) were evaluated for their appearance, film forming capacity, moisture permeability, weight variation and thickness. Placebo film formulations T4 and T6 consisting of locust bean gum (0.6 gm), beeswax (0.1 gm) and crospovidone (4%), 0.3 and 0.9 ml of PEG-200 respectively were selected for drug loading. Drug loaded films (F1 and F2) were characterised for parameters such as weight variation, film thickness, folding endurance, drug content uniformity, in vitro disintegration time, in vitro drug release, tensile strength and surface pH. Composition F2 comprising of locust bean gum (0.6 gm) and 0.9 ml of PEG- 200 was chosen as optimized formulation. Stability studies of optimized drug loaded formulation was done as per ICH guidelines of stability. Locust bean gum appears as a good alternative over the various synthetic polymers utilized in the formulation and development of oral strips/ films.

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