Synthesis Biological Studies of Some New Heterocyclic Compound Derived From 2-Chloro-3-Formyl Quinoline And 4-(Benzyl Sulfonyl) Acetophenone

Saleh, Mohanad; Ayoub, Ala I; Hammady, Ali O.

doi:10.21608/ejchem.2020.26354.2535

Synthesis Biological Studies of Some New Heterocyclic Compound Derived From 2-Chloro-3-Formyl Quinoline And 4-(Benzyl Sulfonyl) Acetophenone

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Education for pure science, University of Mosul

² Department of Renewable Energies , college of Sciences, University of Mosul

³ Remote sensing and Gls , college of Sciences, University of Baghdad

10.21608/ejchem.2020.26354.2535

Abstract

A new series of quinoline chalcones have been prepared from condensations of 2-chloro-3-formyl quinoline (1) with 4-(benzothio) acetophenone(2) and 4-(benzyl sulfonyl) acetophenone(3). The reaction of chalcones(4,5) with bromine gives dibromide(6,7). New pyrazoline derivatives were synthesized by condensation of chalcones (4 or 5) with hydrazine hydrate to give (8,9) and with hydrazine hydrate in glacial acetic acid(gla) to give (10,11) and with phenyl hydrazine to give (12,13). The prepared chalcones (4,5) and dibromide(6,7) and pyrazoline derivative (8-13)have been screened for anti-bacterial activities against two gram positive staphylococcus aureus and staphylococcus epidermidis and two gram negative Escherichia coli and Proteus vulgaris. The synthesized compounds are proven by IR & NMR spectral and physical method.

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