Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives

Maigali, Sohier; Tawfik, Hanaa Awad; Ali, Mansoura; Soliman, Fouad; Mohramb, Maysa E.; Dondeti, Mahmoud Fathy

doi:10.21608/ejchem.2020.27574.2580

Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives

Document Type : Original Article

Authors

¹ National Research center

² 1Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Giza, Egypt.

³ National Research Centre,Dept. of Organometallic and Organometalloid Chemisry

⁴ Organometallic and organometalloid chemistry dept

⁵ a Department of Organometallic and Organometalloid Chemistry, b Microbial Chemistry Department, National Research Centre,

⁶ National Research Centre

10.21608/ejchem.2020.27574.2580

Abstract

Some of Schiff base derivatives were separated by condensing 3-formyl-2-quinolinone with various primary amine derivatives in ethanol, in which water is expelled. Moreover, substituted acryloylphenyliminomethylquinolinone chalcone derivatives were prepared by the process of condensation reaction of aldehyde derivatives with 3-acetylphenylquinolinone in dilute solution of ethanolic sodium hydroxide via Claisen-Schmidt condensation method. Cyclization reaction of the quinolinone chalcones with malononitrile, phenylhydrazine, urea and thiourea were also investigated. The structures of these compounds have been elucidated on the bases of spectral data. The novel products were also evaluated for their antimicrobial activity.

Keywords