Bezafibrate Scaffold Derived Hydrazide-Hydrazones: Synthesis and Antioxidant Activities

Document Type : Original Article

Authors

1 DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA

2 dept. of chemistry, acharya nagarjuna university, guntur

3 dept. of chemistry, Singareni Collieries Women’s Degree College, Kothagudem-507101, Telangana, India

4 Department of Microbiology, Acharya Nagarjuna University, nnagar, Guntur-522510, AP., India

Abstract

A new series of Bezafibrate derived hydrazide-hydrazone analogues were generated by using some five membered, fused heterocyclic and aromatic aldehydes. All the hydrazones were obtained in good yields from methanol at 60-80 °C for 5-8 hours stirring. Moreover, the compounds were also screened after their anti-oxidant activity potentiality at four different concentrations using DPPH method. Among these compounds, compound 6k analogue of bezafibrate was found to be the most active at all the tested concentrations (≈ 40% inhibition at 25 μg/mL ) followed by 6j (4-hydroxy, 3-methoxy 5-bromo analogue ≈ 35% at 25 μg/mL) compared to standard ascorbic acid (49.6% at 25 μg/mL).

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History

  • Receive Date: 13 December 2019
  • Revise Date: 27 February 2020
  • Accept Date: 24 February 2020

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