Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives 	and their Inhibitory Activity on HepG2 Cell Line

Ahmed, Nesreen S.; Alsulami, Eman S.; Badahdah, Khadija O.; Al-Amshany, Zahra M.; Haiba, Mogedda E.

doi:10.21608/ejchem.2020.24391.2451

Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line

Document Type : Original Article

Authors

¹ Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Division, National Research Center,Cairo, Egypt

² Chemistry Dept., Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

³ Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Center, El Buhouth Street, Dokki, Cairo, 12622, Egypt

10.21608/ejchem.2020.24391.2451

Abstract

Abstract:
A new series of 2-phenyl-1,8-naphthyridine derivatives were synthesized via traditional heating and under ultrasonic irradiation to run out comparative study and confirm the utility of the green chemistry in organic synthesis. An improvement in the rates and yields were observed upon carrying out the reactions under environmentally benign protocol. The newly produced compounds were scanned in vitro for their adverse activity on HepG2 (Human liver) carcinoma cell lines. Results revealed that the tested compounds possess an inhibitory effect on the growth of HepG2 carcinoma cells. The naphthyridinyl pyridine derivatives 4c and 5c showed significant cytotoxic activity. The oxo-pyridine derivative4c was more potent than the reference drug doxorubicin (DOX), while the imino-pyridine derivative 5c showed slight reduction in the potency. On the other hand, Mannich bases (2a,c,d,e) showed good activity and the styryl derivatives (6b-d) showed moderate activity when compared to (DOX).

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