The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells

Document Type : Original Article

Authors

1 Department of Therapeutic Chemistry National Research Centre, El-Buhouth St., P.O. 12622, Dokki, Giza, Egypt

2 Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

Abstract

Some new and known substituted 1,2,3,4-tetrahydroacridines incorporated at their position nine with various sulfa drug or thiosemicarbazide moieties were synthesized. Biologically, these compounds were investigated for their antiproliferative activity against human breast cancer (MCF-7) cell line compared to murine fibroblast normal cell line (BALB/3T3). The results were calculated as the IC50 (inhibitory concentration 50%) compared with Cisplatin as control. Furthermore, a docking simulation study was carried out to predict the inhibitory mode of action of the most active compounds.

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History

  • Receive Date: 14 February 2018
  • Revise Date: 09 April 2018
  • Accept Date: 15 May 2018

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