Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast

Gaffer, Hatem; Elapasery, Morsy; Abbas, Dina; Allam, Emad

doi:10.21608/ejchem.2020.22449.2335

Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast

Document Type : Original Article

Authors

¹ Dyeing, Printing and Auxiliaries Department, Textile Industries Research Division, National Research Centre, 33 El-Buhouth Street, Dokki, Cairo 12622, Egypt.

² Dyeing, Printing and Auxiliaries Department, Textile Research Division, National Research Centre, Cairo 12622, Egypt

³ Textile Printing, Dyeing and Finishing Department, Faculty of Applied Arts Helwan University, Cairo 12622, Egypt.

10.21608/ejchem.2020.22449.2335

Abstract

SYNTHESIS of some new Aryl-azopyridone analogues was synthesized through coupling of diverse Diazonium salts with 1-ethyl-4-methyl-2,6-dioxopiperidine-3-carbonitrile. The proper structures for all incorporated derivatives were demonstrated to be confirmed via various physical and spectral analyses performed. The synthesized analogues were probed as cytotoxic agents toward four dissimilar cell lines, in which the results displayed persuasive activities relative to the results of antibiotic standards. In addition, the antioxidant activity of the synthesized analogues was evaluated using ABTS•+ method.

Keywords