Novel Heterocycles via 2-Cyano-N-arylacetamide Synthesis with Docking Studies of Novel Heterocycles as Antimicrobial Agents Utilizing 2-Cyano-N-arylacetamide

Document Type : Original Article

Authors

1 Department of Green Chemistry, National Research Centre (NRC), 33 EL-Bohouth Street (former EL-Tahrir Street), Dokki Giza Egypt

2 Organometallic and Organometalloid Chemistry, Chemical Industries Division, National Research Centre

Abstract

2-CYANO-N-arylacetamide reagent is used in a straight forward synthesis of various interesting nitrogenous heterocycles such as iminocoumarine, thiazole, dihydropyridine and imidazole or benzoimidazole. Molecular docking studies are described to show the most active compounds as antimicrobial agents. Also, Biological testing of these compounds for their antimicrobial activities against some strains of Gram bacteria and strains of fungi has been carried out.

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History

  • Receive Date: 01 January 2020
  • Revise Date: 08 January 2020
  • Accept Date: 08 January 2020

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