Synthesis, Molecular Modeling and Biological Evaluation of Indeno[1,2-b]quinoxaline Derivatives as Antifungal and Antibacterial Agents

Abd El Salam, Hayam A.; El-Bendary, Magda A.; Ibrahim, Medhat; El-Samahy, Fatma A.

doi:10.21608/ejchem.2020.21366.2275

Synthesis, Molecular Modeling and Biological Evaluation of Indeno[1,2-b]quinoxaline Derivatives as Antifungal and Antibacterial Agents

Document Type : Original Article

Authors

¹ Green Chemistry Department, Chemical Industrial Research Division, National Research Centre.

² Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre.

³ Spectroscopy Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza, Egypt, P.O.12622.

10.21608/ejchem.2020.21366.2275

Abstract

The (11H-indeno[1,2-b]quinoxalin-11-ylidene)thiocarbohydrazonewere synthesized and consequently some new novel structures were obtained in a good yields. Their chemical structures were assigned by means of spectral analysis. Molecular modeling at B3LYP/6-31 g (d, p) is utilized to calculate both the optimized structure and vibrational spectra of some studied structures. A promising antimicrobial result was obtained from the new synthesized compounds.

Keywords