Synthesis of Novel N- and C-acyclic Nucleosides Derived from 2-hydrazino-6-methyluracil

Abd El Salam, Hayam A.; Gaafar, A.M.

doi:10.21608/ejchem.2020.21459.2279

Synthesis of Novel N- and C-acyclic Nucleosides Derived from 2-hydrazino-6-methyluracil

Document Type : Original Article

Authors

Hayam A. Abd El Salam ¹
A.M. Gaafar ²

¹ Green Chemistry Department, National Research Centre, 33 EL Bohouthst. (former EL Tahrirst.) – Dokki – Giza – Egypt - P.O.12622.

² Department of Photochemistry,National Research Centre, 33 EL Bohouthst. (former EL Tahrirst.) – Dokki – Giza – Egypt - P.O.12622

10.21608/ejchem.2020.21459.2279

Abstract

The reaction of 2-hydrazino-6-methyl uracil with different aldo- sugars yields the corresponding N-acyclic glycosides. However, some of them have cyclized successfully to form a new fused triazole ring. Apparently, such cyclization depends upon the Stereochemistry of the N-glycoside intermediates that produce the C-glycosides.”

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