Blending and Characterization of Gold Nanoparticles with Omega-3 Oils Induces Antidiabetic, and Antioxidant Activities in-vivo

Soliman, Amira Fawzy; Abdel-Rahman, Mohamed A; Hamad, Hanaa H; Eltamany, Elsayed H; Al-Sherbini, Al-Sayed

doi:10.21608/ejchem.2019.18861.2159

Blending and Characterization of Gold Nanoparticles with Omega-3 Oils Induces Antidiabetic, and Antioxidant Activities in-vivo

Document Type : Original Article

Authors

¹ Department of nutritional chemistry and metabolism, National Nutrition Institute (NNI) - Healthy Minster, Cairo, Egypt

² Assistant Professor of Molecular Toxicology & Physiology of zoology, Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

³ Professor of Environmental science for nutritional chemistry and metabolism. Department of nutritional chemistry and metabolism, National Nutrition Institute (NNI) - Healthy Minster, Cairo, Egypt.

⁴ Professor of Organic chemistry, Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

⁵ Prof. of Photochemistry and Nano chemistry, Department of Measurements, Photochemistry and Agriculture Applications, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza, Egypt.

10.21608/ejchem.2019.18861.2159

Abstract

The aim of the study is to explore the antidiabetic and antioxidant activities of gold nanoparticles (AuNPs) mixed with either flaxseed oil (FLO) or fish oil (FIO). A pyrolysis method was used to prepare AuNPs in oleic acid. The characteristics of the sample were determined by using the transmission electron microscope (TEM) and UV spectroscopy. Male albino rats were divided into two main groups. Group one (n=10 rats) was fed on the basic diet (serves as healthy control). The other group was fed on the high fructose diet (HFD) for four weeks and then was divided into five subgroups. 1st subgroup was fed on HFD only, 2nd and 4th subgroups were fed on HFD mixed with omega-3 oils while 3rd and 5th fed on HFD+ omega-3 oils mixed with AuNPs. Results revealed that there was a significant decrease in glucose level, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index and lipid peroxidation in oils nanoparticles treated groups compared to the HFD group and a significant increase in the homeostasis model assessment of β-cell function (HOMA-β) and Glutathione (GSH). It can be concluded that AuNPs mixed omega-3 oils have more anti-diabetic, hepatic protection and antioxidant properties than omega-3 oils alone.

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