Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives

Mhmood, Helen Abdalhassan; Lafta, Souad Jabbar; Atia, Abdul Jabar Khalf; Al-Bayati, Redha Ibrahim; Abdula, Ahmed Mutanabbi

doi:10.21608/ejchem.2019.16920.2030

Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq

² Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq.

³ chemistry, college of science, Mustansiriyah university

10.21608/ejchem.2019.16920.2030

Abstract

Abstract A novel series of 1,4-benzoxazinone derivatives were synthesized and characterized using FT-IR , 1H-NMR, 13C-NMR and Mass spectroscopy. These compounds were in vitro screened against several bacterial species gram positive and gram negative as well as Candida albicans and found exhibiting moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 1,1‐diphenyl‐2‐picryl hydrazyl (DPPH) radical. Docking study for the potent compound 8 against glucosamine-6-phosphate synthase , the target enzyme for the antimicrobial agents was explored to explain the interactions of the discovered hits with in the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compound as promising antimicrobial agents.

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