Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

Zaki, Nadia G.; Mahmoud, Walaa H.; El Kerdawy, Ahmed M.; Abdallah, Abanoub; Mohamed, Gehad G.

doi:10.21608/ejchem.2019.16748.2019

Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

Document Type : Original Article

Authors

¹ Narcotic Research Department, National Center for Social and Criminological Research (NCSCR), Giza 11561, Egypt

² Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt

10.21608/ejchem.2019.16748.2019

Abstract

Reaction of cocaine (Cn) with Mn(II) and Cu(II) chloride salts afforded complexes of the [M(Cn)Cl(OH2)3]Cl type which were structurally characterized by elemental analysis, conductance measurements, spectroscopic methods and mass spectroscopy. Their thermal properties were studied. The in vitro antitumor activity of the newly synthesized complexes was investigated by MTT assay on MCF-7 and HepG-2 cell lines. Both complexes exhibited promising cytotoxic activity on both cell lines with high safety on normal human cells. Their antifungal activity against Aspergillus fumigatus and Candida albicans and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium and Escherichia coli were also included.

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