Comprehensive Clinical Overview of Gallstones (Cholelithiasis): Epidemiology, Pathophysiology, Diagnosis, and Evidence-Based Management for Healthcare Professionals.

Document Type : Review Articles

Authors

‏ Ministry of National Guard, Saudi Arabia

Abstract

Background: Gallstones (cholelithiasis) are a prevalent digestive disorder affecting millions worldwide, with a higher incidence in women and older adults. While often asymptomatic, a significant minority develop symptoms or complications ranging from biliary colic to life-threatening conditions like cholecystitis, cholangitis, and pancreatitis.

Aim: This article provides a comprehensive clinical overview of gallstones for healthcare professionals, covering epidemiology, pathophysiology, diagnostic approaches, and evidence-based management strategies.

Methods: The review synthesizes current medical knowledge on gallstone formation, which involves an imbalance in bile composition (supersaturation of cholesterol or bilirubin), gallbladder stasis, and genetic, metabolic, and microbial factors. Diagnosis relies heavily on clinical history, physical examination, and ultrasonography as the primary imaging modality, with additional roles for CT, MRI/MRCP, and HIDA scans.

Results: Management is dictated by symptom presence and complication severity. Asymptomatic stones often require no intervention. For symptomatic or complicated disease, laparoscopic cholecystectomy is the definitive treatment. Endoscopic retrograde cholangiopancreatography (ERCP) is crucial for managing common bile duct stones, while conservative and medical therapies have limited, niche roles.

Conclusion: Gallstone disease represents a significant clinical and economic burden. Accurate diagnosis and risk stratification are essential. Surgical removal of the gallbladder remains the cornerstone of treatment for symptomatic patients, providing durable symptom resolution and preventing complications

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Egyptian Journal of Chemistry
Volume 68, Issue 13 - Serial Number 13
(In Loving Memory of Late Professor Doctor”Zeinab M. Nofal” In progress
December 2025
Pages 1313-1324

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History

  • Receive Date: 17 August 2025
  • Revise Date: 07 October 2025
  • Accept Date: 08 October 2025

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