Chemical Composition of Pulicaria undulata (L.) Methanolic Extract and Its Potential Antioxidant and Cytotoxic

Document Type : Original Article

Authors

Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt

Abstract

Natural products play a vital role in the development, design, and discovery of new medications, while also serving as a key source of drugs and biologically active compounds. This study investigates the chemical composition, antioxidant, and cytotoxic properties of the methanolic extract of Pulicaria undulata (L.). Utilizing GC-MS analysis, we identified various bioactive compounds, including fatty acids and terpenoids, contributing to its therapeutic potential. Antioxidant activity was evaluated using DPPH and ABTS assays, revealing concentration-dependent scavenging effects, with IC₅₀ values of 38.46 mg/mL (DPPH) and 33.51 mg/mL (ABTS). Additionally, cytotoxic effects were assessed on human tumor cell lines (HePG-2, MCF-7, PC3), demonstrating selective cytotoxicity, particularly against HePG-2 cells (IC₅₀: 36.59 µg/mL) while sparing normal WI-38 fibroblasts (IC₅₀: 100 µg/mL). These results emphasize the potential of Pulicaria undulata as a valuable source of antioxidants and anticancer compounds, encouraging further investigation for therapeutic uses.

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Egyptian Journal of Chemistry
Volume 69, Issue 2 - Serial Number 2
In Progress
February 2026
Pages 639-646

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History

  • Receive Date: 04 May 2025
  • Revise Date: 26 August 2025
  • Accept Date: 26 August 2025

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