Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus

Document Type : Original Article

Authors

1 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menofia university

2 Chemistry Department, Faculty of Science, Menofia University, Egypt

3 Chemistry Department, Faculty of Science, Menofia University, Shebin El Kom, Egypt

4 Medical Biochemistery and Molecular Biology, Faculty of Medicine, Menofia university, Egypt

Abstract

Background: There is no doubt about the association between the cholecystokinin B receptor (CCKBR) gene and susceptibility to helicobacter pylori (H. pylori) infection. CCKBR gene encodes a G-protein-coupled receptor for gastrin and cholecystokinin (CCK). Several genetic studies have demonstrated an implication of CCK in the feedback control of gastrin release and gastric acid secretion in healthy subjects. Recent studies in patients infected with hepatitis C virus (HCV) refer to the bad effect of H. Pylori infection on the course of liver injury, especially extensive fibrosis.
Objectives: We aimed to investigate whether there is an association between the CCKBR (rs2929180 and rs1800843) single nucleotide polymorphisms (SNPs) and the susceptibility to H. pylori infection in patients with and without HCV.
Subjects and methods: This current work was carried out on 195 subjects. They were classified into three groups: Group I: 65 H. Pylori patients with HCV, Group II: 65 H. Pylori patients without HCV, and 65 age- and gender-matched healthy controls. All subjects underwent genotyping of CCKBR (rs2929180 and rs1800843) by real-time PCR.
Results: The frequency of T/T in CCKBR (rs2929180) was higher in H. Pylori patients with HCV than in H. Pylori patients without HCV and controls (23.1% vs. 7.7% and 0%). The frequency of the C/C and C/A of CCKBR (rs1800843) was higher in H. Pylori patients with HCV than in H. Pylori patients without HCV and controls (13.8% vs. 4.6% and 1.5%) and (32.3% vs. 20% and 12.3%) respectively.
Conclusion: CCKBR (rs2929180 and rs1800843) gene polymorphisms may play a role in determining the degree of H. Pylori infection and HCV severity.

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Egyptian Journal of Chemistry
Volume 68, Issue 13 - Serial Number 13
(In Loving Memory of Late Professor Doctor”Zeinab M. Nofal” In progress
December 2025
Pages 1065-1073

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History

  • Receive Date: 23 January 2025
  • Revise Date: 08 June 2025
  • Accept Date: 22 June 2025

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