Synthesis and Antimicrobial Activity of Novel 2,6-diundecylidenecyclohexan-1-one Derivatives

Document Type : Original Article

Authors

1 Department of Photochemistry, National Research Centre, Cairo, Egypt

2 Natural and Microbial chemistry Department, National Research Center, Egypt

3 Pesticide Chemistry Department, National Research Centre, Egypt

4 Faculty of science, Al-Azhar University

Abstract

Twelve newly prepared compounds starting from cycloheanone are done. Cyclohexanone reacts with undecanal to afford 2,6-diundecylidenecyclohexan-1-one 1. 2,6-Diundecylidenecyclohexan-1-one 1 reacts with urea, and thiourea to afford quinazoline derivatives 2a,b. Cyclohexanone derivative 1 reacts with guanidine, and aminoguanidine to form quinazoline derivatives 3a,b. Compound 1 reacts with semicarbazide, and thiosemicarbazide to give indazole derivatives 4a,b. Also, cyclohexanone derivative 1 reacts with carbon disulfide to afford benzo[b]thiophene derivative 5. Cyclohexanone derivative 1 reacts with hydrazine hydrate, and hydroxylamine to form indazole derivatives 6a,b. Quinazoline derivative 3b reacts with p-chlorobenzaldehyde to afford octahydroquinazoline derivative 7. Also, quinazoline derivative 3b reacts with ribose, and glucose to afford sugar derivatives 8a,b. Antimicrobial screening of new prepared compounds was done against G+ve bacteria, G-ve bacteria, and two fungi. Several compounds show promising antimicrobial activity as compared with reference drug used.

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Egyptian Journal of Chemistry
Volume 68, Issue 13 - Serial Number 13
(In Loving Memory of Late Professor Doctor”Zeinab M. Nofal” In progress
December 2025
Pages 903-909

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History

  • Receive Date: 09 April 2025
  • Revise Date: 30 May 2025
  • Accept Date: 11 June 2025

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