Ameliorative effect of curcumin and curcumin nanoparticles against CFA-induced arthritis in adult male Wistar rats

Hamdy, Soha M.; Hamdy, Esraa A.; Mohamed, Heba R.; Sayed, Ola Nabil

doi:10.21608/ejchem.2025.365369.11388

Ameliorative effect of curcumin and curcumin nanoparticles against CFA-induced arthritis in adult male Wistar rats

Articles in Press

Document Type : Original Article

Authors

¹ Department of Chemistry, Biochemistry Division, Faculty of Science, El Fayoum University, El-Fayoum,

² Department of Zoology, Faculty of Science, El Fayoum University, El-Fayoum,

10.21608/ejchem.2025.365369.11388

Abstract

This research was accomplished to clarify the effect of curcumin (Cur) and curcumin nanoparticles (Cur-NPs) on rheumatoid arthritis (RA). 48 male rats were divided randomly into groups (I): control; group (II): Cur group; group (III): Cur-NPs group; group IV: RA group; group V: Cur Treated (Tr) group; group VI: Cur-NPs Tr group; group VII: Cur Protective (Pr) group; group VIII: Cur-NPs Pr group; There was significant increase in serum MDA, RF, Anti-CCP, IL-6, and TNF- α levels and a greatly marked drop in levels of total antioxidant (TAC) in the rheumatoid arthritis (RA) group in comparison to control group with improvement their levels in groups(V- VIII). In conclusion, our result showed that the administration of Cur and Cur-Nps provided antioxidant and anti-arthritic effects against the toxicity of CFA. The histological and x-ray findings confirm the biochemical observations.

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