Herbal Phytoconstitutes: Natural Weapon Against Lung Cancer

Sanad, Hadeel; Kamel, Kamel Mahmoud; El Motayam, Amira Kamal; Shoukry, Mouchira Aly; El Hawary, Seham Salah Eldin

doi:10.21608/ejchem.2025.365750.11408

Herbal Phytoconstitutes: Natural Weapon Against Lung Cancer

Document Type : Review Articles

Authors

¹ department of pharmacognosy, faculty of pharmacy, Cairo university.

² department of pharmacognosy, faculty of pharmacy, MUST university, cairo

³ Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street

⁴ pharmacognosy Department, faculty of pharmacy, Cairo university

⁵ Pharmacognosy Department, Faculty of Pharmacy, Cairo University

10.21608/ejchem.2025.365750.11408

Abstract

By the twenty-first century, lung cancer has become well-known as one of the most frequent cancers. Nowadays, Lung cancer ranks second globally regarding new cases and first globally regarding cancer-related deaths. To fight this spreading; surgical procedures, radiation treatment, chemotherapy or combination of these strategies is commonly used. Thanks to their phytochemical compounds; Many plants have proved their efficacy as anticancer agents by different mechanisms as Allium sativum, Curcuma longa, Camellia sinensis and Panax ginseng etc. by Apoptosis, cell cycle arrest, Tyrosine Kinase inhibitors, PI3K/AKT/mTOR inhibitor pathway and Autophagy. In this review article, the effect of using natural plants as anticancer agents and the possibility to use natural plants extracts in combination with chemotherapy to reduce chemotherapy side effects, or to enhance the anticancer activity of chemotherapy, will be examined.

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