A Comparative Study On The Effects Of Dietary Supplementation With Garlic (Allium Sativum) And Clove (Syzygium Aromaticum) On Ghrelin Levels And Some Physiological Parameters.

Ibrahim, Marina M.; Seifelnasr, E.; Morsi, Asmaa S.; Ibrahim, Marwa A.; Bakeer, Manal R.

doi:10.21608/ejchem.2025.365582.11393

A Comparative Study On The Effects Of Dietary Supplementation With Garlic (Allium Sativum) And Clove (Syzygium Aromaticum) On Ghrelin Levels And Some Physiological Parameters.

Articles in Press

Document Type : Original Article

Authors

¹ Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Egypt.

² Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Egypt.

10.21608/ejchem.2025.365582.11393

Abstract

This study focused on evaluating the effects of garlic powder and clove powder supplementation on ghrelin levels, body weight, hematological parameters, and metabolic markers in male rats. Methods: Thirty adult male Swiss albino rats were divided into three groups and studied over two months. Group 1 (control) received a standard rat diet, Group 2 was supplemented with 5% garlic powder in their standard diet, and Group 3 received clove powder at a daily dosage of 30 mg/kg body weight in their diet. At the end of the experiment, blood samples were collected, and the rats' final body weights were measured. Garlic supplementation significantly reduced ghrelin levels (p≤0.05), whereas clove supplementation resulted in a significant increase (p≤0.05) relative to the control group. Body weight analysis showed a significant increase in the clove group from the fourth week onward, while the garlic group exhibited a significant decrease from the first week. Hematological analysis demonstrated a notable elevation in RBC count, WBC count, and hemoglobin concentration in both treatment groups, while platelet count decreased significantly. Additionally, cholesterol and blood glucose levels significantly decreased in both groups, with triglyceride levels notably lower in the garlic group.These findings suggest that garlic and clove supplementation have contrasting effects on ghrelin levels and body weight while exerting beneficial influences on hematological and metabolic parameters.

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