A Biochemical Study on Functionality of Body Organs of Rats Fed Various High Milk Proteins Diets

Document Type : Original Article

Authors

1 Department of Food Technology, Palestine Technical University-Kadoorie, Palestine

2 Alexandria University Faculty of Agriculture · Department of Dairy Science Ph.D. Immunovirology

3 Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Egypt

4 Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt.

Abstract

A high-protein diet (HPD) is frequently linked to biochemical and physiological alterations in the heart, kidney, and liver, among other important organs. Within the framework of HPD, this study analyzes the effects of various milk proteins and whey protein treatments on organ function and biochemical indicators in rats. The study aimed to evaluate the effects of milk-derived proteins, specifically casein, whey proteins, and both fermented and hydrolyzed milk proteins, on metabolic and enzymatic processes in key organs, while also considering potential risks. The findings of this study indicate that feeding rats a diet high in various forms of milk protein leads to a significant (p≤ 0.0001) decrease in testosterone levels, an increase in high-density lipoproteins (HDL), along with elevated levels of uric acid and urea. However, the study found no significant impact on liver enzymes. Additionally, the albumin/globulin ratio in the blood of rats on a high-protein diet decreased. Overall, the results suggest that high protein intake can worsen existing kidney problems particularly in cases of deteriorated kidney function. While it raises uric acid and urea levels and lowers testosterone levels, it also improves HDL levels.

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History

  • Receive Date: 01 March 2025
  • Revise Date: 26 April 2025
  • Accept Date: 03 May 2025

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