A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range

Said, Basmat Amal; Shoukry, Eman Mohamed; Mohamed, Eman Fares; Hendawy, Hassan; Khaled, Elmorsy A

doi:10.21608/ejchem.2025.361974.11328

A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range

Articles in Press

Document Type : Original Article

Authors

¹ Faculty of Science (Girls), Al-Azhar University, Naser City, Egypt

² Egyptian Drug Authority, Giza, Egypt

³ Applied Organic Chemistry Department, National Research Centre, El Bohouth St., Dokki, 12622 Giza, Egypt

10.21608/ejchem.2025.361974.11328

Abstract

The present study introduces a novel screen-printed planner potentiometric sensor for sensitive determination of eletriptan hydrobromide (ELE). Comprehensive and deep optimization trials were carried out concerning the nature and content of the sensing element, anionic sites, plasticizer, carbonaceous nanomaterial, performance under different pH values, and other electroanalytical parameters. Among the different fabricated sensors, the printed sensor integrated with the 2,6-di-o-methyl β-cyclodextrin-multiwall carbon nanotubes nanocomposites (β-CD/MWCNTs) exhibit ideal Nernstian slope value (59.7±0.6 mV decade-1) within a linear dynamic ELE concentration range from 10-8 to 10-3 mol L-1 and limit of detection 1.0×10-8 molL-1. Moreover, the presented disposable sensors show high potential stability with a prolonged operational lifetime, and a fast response time of 4s, representing an efficient analytical tool for fast and sensitive assay of ELE contents in authentic and marketed pharmaceutical tablets with acceptable average recoveries (100.11±1.3%).

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