Study of the Radioprotective Efficiency of Administration of Rutin and Cysteine in Irradiated Pregnant Rats and Their Fetuses

Morsi, Reham M.; Mansour, Doaa S.; Abd Elmonem, Hanan A.; Shahin, Wafaa M.; El-Sayed, El-Sayed R.

doi:10.21608/ejchem.2025.343281.10956

Study of the Radioprotective Efficiency of Administration of Rutin and Cysteine in Irradiated Pregnant Rats and Their Fetuses

Document Type : Original Article

Authors

¹ Biological Application Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.

² Radiation protection and civil defense Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.

³ Plant Research Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.

10.21608/ejchem.2025.343281.10956

Abstract

The present study was conducted to investigate the potentially protective effect of rutin and cysteine on pregnant rats who had received whole-body gamma irradiation and the development of their fetuses. In the present work sixty female albino rats were arranged into six equal groups. Control (G1); 2nd group: will receive saline then irradiation (2Gy) and served as irradiated control (G2); 3rd group: will receive rutin (1.064 mmol/kg, oral) daily for two weeks (G3); 4th group will receive rutin (1.064 mmol/kg, oral) daily for two weeks and then irradiated (2 Gy) (G4); 5th group: will receive \ cysteine (30 mg/kg,i.p) (G5); 6th group: will receive cysteine (30 mg/kg,i.p) 30 min. before irradiation (G6). The rats exposed to 2Gy gamma-irradiation increased the MDA, E2, FSH and LH levels significantly as compared to control group. In contrast; a significant decrease in the levels of SOD, CAT, progesterone, prolactin, AMH, IgM and IgG were observed in irradiated group as compared to control. The oral supplementation of rutin and cysteine has significantly attenuated the severity of irradiation. Also, the whole body γ-irradiation (2 Gy single dose) caused embryonic death and embryos replaced by residual bodies. The fetal wight, fetal body length, fetal head length and the fetal head width were significantly decreased in irradiated group when compared to control group. While, the treatment with rutin or cysteine in G4 and G6 before the whole body γ-irradiation caused a nonsignificant decrease in these mentioned measurements, as compared with the control.

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