Total Phenolic Contents and Antioxidant Activity of Pomegranate (Punica Granatum L.) Peel Extracts against Oxidative Stress Induced by Lambada Cyhalothrin Insecticides on Male Albino Rats

Abd Elfatah, Awad; Abdel Mobdy, Yasmin; Osama M. Abdel-Fatah, Osama M. Abdel-Fatah; Abdelrahim, Emam; Hassan, Marwa Emam

doi:10.21608/ejchem.2025.349994.11093

Total Phenolic Contents and Antioxidant Activity of Pomegranate (Punica Granatum L.) Peel Extracts against Oxidative Stress Induced by Lambada Cyhalothrin Insecticides on Male Albino Rats

Document Type : Original Article

Authors

awad Abd elfatah ¹
yasmin Abdel Mobdy ²
Osama M. Abdel-Fatah Osama M. Abdel-Fatah ³
Emam Abdelrahim ⁴
marwa emam hassan ⁵

¹ Research Institute of Medical Entomology

² , Faculty of Agriculture, Cairo University

³ Biochemistry Department, Faculty of Agriculture, Cairo University, Egypt.

⁴ Biochemistry Department, Faculty of Agriculture, Cairo University, P. Box 12613, Gamma St, Giza, Egypt

⁵ toxicology ,research institute of medical entomology

10.21608/ejchem.2025.349994.11093

Abstract

This study assess the pomegranate's antioxidant capacity and total phenolic content and its role as antioxidant against oxidative damages and alteration in biochemical, hematological and hormonal indices and renal and liver tissues after exposure to Lambda-cyhalothrin in experimental animals. The findings indicate that DPPH (1, 1diphenyl-2-picryl hydrazyl) and ABTS radical assays produced the strongest antioxidant activity, exceeding those of KMnO4. Pomegranate peels contain 77.09g/100g total carbohydrate, 17.08g/100g total soluble sugar, 2.27g/100g total phenols and 2.04 g/100g total flavonoids. Lambdacyhalothrin had adverse effect on human and animal, since it modifies the activities of the kidneys and liver, hematological parameters and modify the organs' histological structure. Pomegranate peels improved toxicity induced by this insecticides because pomegranate peels contain high level of antioxidant compounds.

Keywords

Main Subjects