This study aims to synthesize hesperidin oxime from hesperidin, chiral separation by HPLC method and comparative study of two enantiomers as anti-inflammatory agents by docking them with Proto-oncogene serine/threonine-protein kinase Pim-1 using MOE software (4.2). The structure of the synthesized product was validated through UV, IR,1H-NMR, and13C-NMR spectroscopic techniques. Hesperidin-oxime was separated chirally in normal phase mode employing polysaccharide-based chiral stationary phases, namely Chiralcel® OD-H, Chiralcel® OD-RH, and CHIRALPAK® AD-3R, under both normal and polar organic phase modes. Molecular docking shows that S- hesperidin oxime gave better binding affinity towards pim-1 compared to R- hesperidin oxime.
BOUANINI, M., Belboukhari, N., Sekkoum, K., & Haddad, D. (2025). Synthesis, Enantio-Separation and Molecular Docking Study of Hesperidin-Oxime. Egyptian Journal of Chemistry, 68(5), 401-408. doi: 10.21608/ejchem.2025.333625.10739
MLA
Meriem BOUANINI; Nasser Belboukhari; Khaled Sekkoum; Djawhara Haddad. "Synthesis, Enantio-Separation and Molecular Docking Study of Hesperidin-Oxime", Egyptian Journal of Chemistry, 68, 5, 2025, 401-408. doi: 10.21608/ejchem.2025.333625.10739
HARVARD
BOUANINI, M., Belboukhari, N., Sekkoum, K., Haddad, D. (2025). 'Synthesis, Enantio-Separation and Molecular Docking Study of Hesperidin-Oxime', Egyptian Journal of Chemistry, 68(5), pp. 401-408. doi: 10.21608/ejchem.2025.333625.10739
VANCOUVER
BOUANINI, M., Belboukhari, N., Sekkoum, K., Haddad, D. Synthesis, Enantio-Separation and Molecular Docking Study of Hesperidin-Oxime. Egyptian Journal of Chemistry, 2025; 68(5): 401-408. doi: 10.21608/ejchem.2025.333625.10739
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