Efficacy of Cinnamon Extract in Mitigating the Hepato-Renal Toxicity Influenced by Bisphenol A

Dahham, Alaa; Elrayes, Samir; Ahmed, Nadia; Abdelrazek, Heba

doi:10.21608/ejchem.2025.338234.10855

Efficacy of Cinnamon Extract in Mitigating the Hepato-Renal Toxicity Influenced by Bisphenol A

Document Type : Original Article

Authors

¹ chemistry, faculty of science, suez canal university

² Suez Canal University

³ zoology department, faculty of science Suez canal university

⁴ Psephology department faculty of vet, Suez canal university

10.21608/ejchem.2025.338234.10855

Abstract

This study explored the ameliorative influence of cinnamon aqueous extract (CIN) in counteracting bisphenol A's (BPA) toxic and negative effects on male Albino rats. The male rats (n = 24) were allocated into 4 groups, each with 6 rats. The first group was administered distilled water and corn oil, the 2nd group was administered cinnamon extract 400 mg/kg (20% v/v in distilled water), the 3rd group received 10 mg BPA /kg (1% w/v in corn oil), and the 4th group was given both BPA and cinnamon extract daily for 3 months. The gain in body weight, homeostasis model assessment–estimated insulin resistance (HOMA-IR), oral glucose tolerance test (OGTT), leptin, resistin, adiponectin, thyroid hormones T3 and T4, lipid profile, albumin, total protein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assessed, Moreover, antioxidant capacity (TAC), interleukin-1 beta (IL-1β), malondialdehyde (MDA), creatinine, urea, uric acid, hematological examination; the hemoglobin, RBCs count, hematocrit, erythrocyte indices, total leucocytic count and differential leucocytic count were assayed. Also, liver and kidney tissues were undergoing histopathological investigations. BPA-treated rats showed significant increases in the OGTT, leptin, resistin, T3, AST, ALT, IL-1β, MDA, TC, TG, urea, uric acid, and creatinine. While significant reduction happened with BPA-treated rats in the adiponectin, total protein, TAC, albumin, and HDL. However, no significant differences in body weight, HOMO-IR, Insulin, T4, and all hematological indices. The BPA-induced injury of renal and hepatic tissues. Improved metabolic parameters and histopathological retrogressive deviations were detected in rats with co-administered CIN and BPA. Adding CIN enhances and mitigates the negative influences of BPA on metabolism via CIN antioxidant properties and other positive characterization by different mechanisms.

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