5´-cyanomeridianine G analogues produce from 3-cyanoacetyl indole accomplished in to steps by treatment with a mixture ofpiperidine andtriethylorthoformate in DMF and then cyclization of the resulting enaminonitrile with guanidine and thiourea are described.
The biological evaluation against a range of cancer cells lines showed that indolylpyrimidinethione6was more cytotoxic against Lung carcinoma cell line (A549) with inhaibition activity of 95.4 % and it has the highst antioxidant activities. While the cyanomeridianine G 5 showed high cytotoxic activity against MCF7, A549 and HCT116 with 100, 88.6 and 74.6 % inhibition in cell viability, respectively.
Radwan, N., darwish, E., & abdellatif, A. (2025). Synthesis, Docking and Cytotoxicity Evaluation of 3- heterocycles as Potential Anti-Cancer Agents. Egyptian Journal of Chemistry, 68(8), 227-239. doi: 10.21608/ejchem.2024.335435.10777
MLA
Naglaa Fathy Radwan; Elham darwish; abdellatif abdellatif. "Synthesis, Docking and Cytotoxicity Evaluation of 3- heterocycles as Potential Anti-Cancer Agents", Egyptian Journal of Chemistry, 68, 8, 2025, 227-239. doi: 10.21608/ejchem.2024.335435.10777
HARVARD
Radwan, N., darwish, E., abdellatif, A. (2025). 'Synthesis, Docking and Cytotoxicity Evaluation of 3- heterocycles as Potential Anti-Cancer Agents', Egyptian Journal of Chemistry, 68(8), pp. 227-239. doi: 10.21608/ejchem.2024.335435.10777
VANCOUVER
Radwan, N., darwish, E., abdellatif, A. Synthesis, Docking and Cytotoxicity Evaluation of 3- heterocycles as Potential Anti-Cancer Agents. Egyptian Journal of Chemistry, 2025; 68(8): 227-239. doi: 10.21608/ejchem.2024.335435.10777
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