Document Type : Original Article
Authors
1
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
2
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University , Jeddah, Saudi Arabia
3
Production of Bio-products for Industrial Application Research Group, King Abdulaziz University, Jeddah, , Saudi Arabia
4
Hematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
5
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia
6
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
7
Biochemistry Department, Faculty of Science,Ain Shams University, Cairo, Egypt
Abstract
Saudi Arabia charaecterized in Arabian region with valuable flora medicinal plants. In the current study, we investigated the active ingerdeints and potential of methanol extracts of Walnut leaves (WL), Flaxseed (FL) Chamomile (CH), Arnica (AR) , Sage (SG) and Evening primrose (EP). as antioxidant, antibacterial and wound healing effeacy in rats. In current study, the highest inhibitory effect of IC50 against protein denaturation was detected for ER. Anti-inflammatory activity obtained half maximal inhibitory concentration (IC50) of various plant extracts with a different solvent. The average of zones of inhibition of sage and evening primrose with zone 20 at 200mg/0.5ml had very high significant differences compared to positive control whereas they do not have inhibition zones at concentration 5mg/0.5ml. The walnut, flaxseed, chamomile and arnica at different concentration have no inhibition zones against MRSA. Data obtained showed that, a significant decreased in the levels of hydroxyproline (p<0.001) content , reduced glutathione(p<0.01) , MPO (p<0.01) and EGF-beta (p<0.001) in diabetic rats compared with normal control. Diabetic rats treated with either extracts of Walnut leaves (WL), Flaxseed (FL), Chamomile (CH), Sage (SA), Arnica (AR), Evening primrose (ER) showed improvement in these parameters compared with untreated (p<0.001). But the ER is the most potent than other extract. It was concluded that Sage (SG) showed antimicrobial against MERSA at high concentrations compared with other extracts. The WL demonstrated the maximum one. While Evening primrose showed potent inflammatory effect and potent wound healing in diabetic rats.
Keywords
Main Subjects
)
View on SCiNiTO