Schiff bases performance and challenge: Chemical synthesis and current state of biological activities

Alammari, Sara S.; Aroua, Lotfi M.; Alminderej, Fahad M.

doi:10.21608/ejchem.2024.333199.10741

Schiff bases performance and challenge: Chemical synthesis and current state of biological activities

Document Type : Review Articles

Authors

¹ Department of Chemistry, College of Science, Qassim University, Qassim, 51452, Kingdom of Saudi Arabia.

² Laboratory of (Bio)Organic, Structural and Polymer Chemistry (LR99ES14), Department of Chemistry, Faculty of Sciences of Tunis, Tunis El-Manar University, El-Manar, I 2092 Tunis, Tunisia.

³ Carthage University, Faculty of Sciences of Bizerte, 7021 Jarzouna, Bizerte, Tunisia.

10.21608/ejchem.2024.333199.10741

Abstract

Several structure incorporating Schiff bases found multiple applications in different field. Several therapeutic compounds in the anti-cancer, anti-hypertensive, anti-microbial, anti-fungal, and anti-ulcer segments have been produced using the moiety, which has become an essential anchor for the creation of novel pharmacologically active medicines. Since they are pharmacophoric and synthetically possible, Schiff bases have been actively sought after in the creation of novel derivatives and analogues. As a result, they have become one of the most sought-after and essential pharmacophores for drug development. A broad range of biological activities have been made possible by the different substituents and their varying patterns surrounding the Schiff base nucleus. Furthermore, theses moiety serves as a building block for the synthesis of several lead compounds, novel chemical entities, and therapeutic candidates.

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