Pyrimidine as a naturally occurring bioactive ring and its importance in different arenas

Mohamed, Mosaad Sayed; Fatahala, Samar S.; Abd El-Hameed, Rania Helmy; Mohamed, Mariem El Saeed

doi:10.21608/ejchem.2024.299076.9897

Pyrimidine as a naturally occurring bioactive ring and its importance in different arenas

Document Type : Review Articles

Authors

¹ Pharmaceutical organic chemistry , faculty of pharmacy , helwan university, cairo,egypt

² Pharmaceutical Organic Chemistry Department, Faculty of pharmacy, Helwan University

³ Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Helwan, Egypt.

10.21608/ejchem.2024.299076.9897

Abstract

The pyrimidine ring is widely known for its biological activity through history, either by itself or attached to other heterocyclic rings. The importance of pyrimidine is due to its presence in the nucleic acid, in addition to its presence in natural and synthetic drugs. Based on the ring significance, that’s an overview of the recent pyrimidines synthesis, reactions and its different biological activities over the past three years. It was shown that it has a generous contribution to the pharmaceutical industry. Scientists are still working on its derivatives to get promising results in different areas, especially as anticancer agents.

Keywords