Document Type : Original Article
Authors
1
Biological Anthropology Department, Medical Researches and Clinical Studies Institute– National Research Centre Cairo, Egypt.
2
Medical Biochemistry Department, Medical Research and Clinical Studies National Research Centre, Doki, Giza, Egypt.
3
Child health department, medical research and Clinical Studies, National Research Centre, Cairo, Egypt.
4
Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
5
Department of Pediatrics, Faculty of Medicine for boys Al-Azhar University, Cairo, Egypt.
6
Clinical Pathology, Faculty of Medicine – Delta University for Science and Technology, Gamasa, Egypt.
Abstract
Abstract
Background: Diabetic children and adolescents with type 1 diabetes are susceptible to infections and complications due to potential immune dysfunction. Toll-like receptor 1 (TLR1) is a mediator of the innate immune response and insulin-like growth factor 1 (IGF-1), which play crucial roles in immunity and growth, respectively. Impaired glycemic control is associated with elevated TLR1 and Reduced IGF-1 in children with type 1 diabetes
Methods: A cross-sectional study involving 140 children, aged 6-18 years, was conducted, including three groups: (group 1) healthy controls (HbA1c < 6%). We categorized diabetic patients into: (group 2) good HbA1c level < 8%, and (group 3) poor glycemic diabetic patients HbA1c level > 9%. Clinical data, anthropometry, glycated hemoglobin (HbA1c), insulin growth factor-1, and serum TLR1 levels were assessed.
Results: Children with poor glycemic control with HbA1c > 9% had statistically significant higher TLR-1 levels, BMI Z scores, waist/hip, waist/height, and skin fold thicknesses compared to those with HbA1c <8% (P < 0.05). However, IGF-1 showed a lower level in diabetic patients compared to the control group.
Conclusions: Our findings suggest that poor glycemic control in children with type 1 diabetes and increased adiposity is correlated with increased levels of TLR1 and IGF-1, potentially contributing to a heightened inflammatory state and increased risk of complications.
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