The following new compounds have been produced: iminopyran, dihydropyridine, thiophene, tetrahydrobenzo[b]thiophene, and dihydrothiazole. The specific compound structures were verified by elemental analysis, spectral approaches, and the production mechanisms were explored. The newly synthesized compounds showed encouraging inhibitory efficacy against bacteria and fungi, according to the data that were reported. Two bacterial species that are gram-positive (Staphylococcus aureus and Bacillus subtilis) and two bacterial species that are gram-negative (Escherichia coli and Pseudomonas aeuroginosa) were used in the test of the synthesized compounds' anti-microbial activities. The compounds were evaluated for their antifungal properties against two fungi, Aspergillus flavus and Candida albicans, in order to ascertain their minimum inhibitory concentration (MIC). Generally, the newly synthesized substances had strong antibacterial action against the microorganisms listed before.
Abdel Reheim, M. A. M., Abdel Hafiz, I. S., Darweesh, R. M., & Sophy, M. A. E. (2025). 2-Cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide as a building block for developing new azole and azine derivatives and assessing their biological properties. Egyptian Journal of Chemistry, 68(6), 189-207. doi: 10.21608/ejchem.2024.305844.10048
MLA
Mohamed Ahmed Mahmoud Abdel Reheim; Ibrahim Saad Abdel Hafiz; Reem Mustafa Darweesh; Mohamed Ahmed Elian Sophy. "2-Cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide as a building block for developing new azole and azine derivatives and assessing their biological properties", Egyptian Journal of Chemistry, 68, 6, 2025, 189-207. doi: 10.21608/ejchem.2024.305844.10048
HARVARD
Abdel Reheim, M. A. M., Abdel Hafiz, I. S., Darweesh, R. M., Sophy, M. A. E. (2025). '2-Cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide as a building block for developing new azole and azine derivatives and assessing their biological properties', Egyptian Journal of Chemistry, 68(6), pp. 189-207. doi: 10.21608/ejchem.2024.305844.10048
VANCOUVER
Abdel Reheim, M. A. M., Abdel Hafiz, I. S., Darweesh, R. M., Sophy, M. A. E. 2-Cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide as a building block for developing new azole and azine derivatives and assessing their biological properties. Egyptian Journal of Chemistry, 2025; 68(6): 189-207. doi: 10.21608/ejchem.2024.305844.10048
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