Design, sequential synthesis, kinase inhibitors comparative docking, MD simulations, 99mTc-coupling and in-vivo studies of novel pyrazolopyrimidine derivatives

Document Type : Original Article

Authors

• Wafaa Abdou Zaghary ¹
• Dina Adel ²
• basma Mohamed ³
• Tamer Nasr ⁴
• Khaled El-Adl ⁵
• tamer mostafa sakr ⁶

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.

² Pharmaceutical Chemistry Department, Faculty of Pharmacy, MSA University, Cairo, Egypt

³ Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, 13759, Cairo, Egypt

⁴ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Egypt

⁵ Heliopolis University

⁶ Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

Abstract

Keywords

• Pyrazolopyrimidines, Comparative docking, Kinase inhibitors, 99mTc-coupling, Tumor imaging
• MD simulation

Main Subjects

• Pharmaceutical Chemistry